INS and metabolic dysfunction-associated steatohepatitis: In a Meta-analysis study to assess Metformin, eleven RCTs (671 participants, 27% diabetic; six RCTs in NASH with post-treatment histology, three with a low bias risk), the results showed that anorexigenic and weight-loss, decreases gastrointestinal glucose absorption and increases insulin sensitivity, and AMP kinase-mediated oxidative glucose and lipid metabolism have been accrued in these patients.