Indeed, IL-10 inversely correlates with T2DM and has been shown to inhibit IL-6-induced IR, attenuate MCP-1 secretion, and promote GLUT-4 and IRS-1 expression (Lumeng et al., 2007a; Gonzalez-Periz and Claria, 2010). This evidence concerns the gene IL6 and type 2 diabetes mellitus.