IL10 and Autoimmunity: Protective contributions of regulatory B cells in mouse models of autoimmunity and allergy include B cell-intrinsic IL10 production, often corresponding with innate-like (MZ B and B1 B cell) phenotypes (Wolf et al., 1996; Zhou and Hansson, 1999; Fillatreau et al., 2002; Mizoguchi et al., 2002; Amu et al., 2010).