B cell IL10 production can be decreased in induced autoimmune models but expanded in genetically predisposed autoimmune mice (Yanaba et al., 2009), and is also increased in subsets of patients with various autoimmune diseases, including those with rheumatoid arthritis, Sjögren’s syndrome, blistering skin disease, multiple sclerosis, and SLE (Amel Kashipaz et al., 2003; Iwata et al., 2011b). The gene discussed is IL10; the disease is systemic lupus erythematosus.