This approach revealed alterations in the expression of 16 transcripts in MDD versus C. Expression of 13 of these genes was downregulated, including: TOB1, NR4A2, EGR1, CD69, TIPARP, ADM, PPP1R3C, CXCR7, NR4A3, SLC19A2, EEF1A1, CCDC58, and SYTL4 (Table 4). This evidence concerns the gene MIX23 and major depressive disorder.