ACHE and Alzheimer disease: AChE inhibitors such as galanthamine 1 (GAL; Reminyl) [1], donepezil 2 [2], tacrine 3 [3], rivastigmine 4 (Exelon) [4] (Figure 1), and huperzine A (HupA) [5] are the group of drugs most developed and approved for AD symptomatic treatment.