GSK2118436 (a.k.a. dabrafenib) is an ATP-competitive inhibitor of mutant B-Raf, WT B-Raf and WT Raf-1 developed by GlaxoSmithKlein (GSK) in clinic trial (NCT00880321), which examined patients with melanoma, brain metastases, in other solid tumours it was determined to be safe and elicited responses. The gene discussed is BRAF; the disease is melanoma.