Mutations at the BRAF, KRAS, EGFR genes or the chromosomal fusion between anaplastic lymphoma kinase (ALK) and ROS (oncogene that belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes, originally detect in the v-ros retrovirus) tyrosine kinases are detected in approximately 50% of NSCLC. The gene discussed is ROS1; the disease is non-small cell lung carcinoma.