PF-04691502 suppressed transformation of avian cells in response to either WT or mutant PIK3CA. PF-04691502 inhibited tumor growth in various xenograft models including U87 (PTEN null), SKOV3 (PIK3CA mutant), and gefitinib (EGFR inhibitor) and erlotinib-resistant NSCLC [202]. This evidence concerns the gene EGFR and non-small cell lung carcinoma.