CHRNA2 and schizophrenia: This was further supported by the validation of miR-181b MREs within the 3′-UTRs of the schizophrenia susceptibility genes DISC1 [55-57], ENKUR [58] and GPR78 [59], as well as the nicotinic acetylcholine receptor CHRNA2, and the potent binding site in KCNMB2, involved in controlling neuronal excitability by functioning as a subunit in large conductance voltage and calcium−activated potassium channels – also known as BK, MaxiK, or Slo channels [60,61].