Outside of the CNS, the roles played by Class IIa HDACs in regulating transcriptional programs relating to skeletal myogenesis, cardiac hypertrophy, and thymocyte development (Lu et al. 2000b; McKinsey et al. 2000; Zhang et al. 2002; Haberland et al. 2009; Parra and Verdin 2010; Watson et al. 2012) raise the question as to whether these functions may be influenced by signals that promote SMRT-mediated co-shuttling independent of the classical export pathways. Here, NCOR2 is linked to cardiac hypertrophy.