To date, several molecules have been evaluated and proposed as potential biomarkers in HNSCC, including EGFR, cyclin D1 (CCND1), Ki67 antigen, FAS, FASL, BCL2, BCL2L12, TP53, P27, vascular endothelial growth factor (VEGF), matrix metallopeptidases (MMPs), and kallikrein-related peptidases (KLKs)[7,42-46]. This evidence concerns the gene EGFR and head and neck squamous cell carcinoma.