For instance, BCL2L12, a member of the BCL2 family of apoptosis-related genes, is overexpressed in undifferentiated nasopharyngeal carcinoma[43] and in poorly differentiated TSCC, whereas its mRNA levels are lower in LSCC of advanced TNM stage, compared to early-stage laryngeal tumors[45]. This evidence concerns the gene BCL2L12 and undifferentiated carcinoma of nasopharynx.