On the other hand, it is generally believed that intracellular PKC is activated by the diabetes-induced accumulation of its co-factor, diacylglycerol, inside the cells[48] and that, once activated, PKC undergoes autophosphorylation via translocation from the cytosol to the plasma membrane and other subcellular compartments[41]. The gene discussed is PRRT2; the disease is diabetes mellitus.