Nociceptin/orphanin FQ (N/OFQ) [15,16] an endogenous ligand for the N/OFQ peptide (NOP) receptor, modulates various biological functions in the CNS, including nociceptive sensitivity, stress, anxiety, learning, memory and cytokine release [17]; all of which are affected by PTSD. The gene discussed is PNOC; the disease is Anxiety.