Chromosome 1 is also implicated in early onset of Alzheimer's disease through mutation in presenilin 2 gene (PS2) [23], as well as in infantile neuronal ceroid lipofuscinosis, which presents with dementia, among other core symptoms [24], but there is no such finding relating chromosome 1 defect with FTD until presently. Here, PSEN2 is linked to early-onset autosomal dominant Alzheimer disease.