NFKB1 and acute myeloid leukemia: Furthermore, similar effects were seen when BMS-345541 was added together with rapamycin; the presence of the NF-κB inhibitor then further decreased AML cell viability and caused a gradual and strong increase in lysosomal acidity with maintenance of the rapamycin-induced accumulation of cells in the G0/1 phase during a 48-hour culture period.