Co-immunofluorescence staining using anti-Reelin and anti-ADAMTS-4 or -5 antibodies confirmed a close association of Reelin with ADAMTS-4 in sr in both wild-type and 3xTg-AD mice (Fig. 7A,B), but not with ADAMTS-5 (Fig. 7C,D). This evidence concerns the gene ADAMTS5 and Alzheimer disease.