Moreover, patients with classic CF and ≤5% CFTR-mediated Cl− secretion consistently presented faster decline rates of pulmonary function [32], [33] (Fig.3-D, dashed line), than Non-Classic CF patients retaining residual (Fig.3-D, dotted line) or normal CFTR functions (Fig.3-D, solid line, p = 0.001 by Kruskal-Wallis test). The gene discussed is CFTR; the disease is cystic fibrosis.