CFTR and lung disorder: Interestingly, and corroborating such prediction among these four, there is a 19-year old patient with the F508del/G85E genotype, moderate PI (FEE = 103.89 μg/g) and ∼12% of CFTR function (Fig.S2-C, Table S1) who recently (last 11⁄2 yr) started to progress from a relatively mild to moderate-severe lung disease, with five pulmonary exacerbations plus surgery to remove nasal polyps associated with a strong sinusitis.