Interestingly, targeted deletion of the Ppp1cc gene (Ppp1cc −/−), eliminating both Ppp1cc1 and Ppp1cc2 isoforms, results only in male infertility due to highly impaired spermatid morphogenesis and an inability to spermiate, so that the epididymides of Ppp1cc −/− mice are virtually devoid of spermatozoa [12], [23]. The gene discussed is PPP1CC; the disease is male infertility.