TNF and major depressive disorder: In the patient group, absolute values of TNF-α correlated significantly with FACIT scores (Spearman’s Rho = −0.19, p = .05), HAD depression scores (Spearman’s Rho = 0.35, p = .001) as well as the HAD anxiety scores (Spearman’s Rho = 0.21, p = .03).