However, the concentrations of other cytokines, including IL-6 (naïve 70.8±0.5, early 70.7±0.8, advanced 3585.6±53.4 pg/ml, p<0.001, one-way ANOVA), IL-10 (naïve 0.0±0.0, early 0.0±0.0, advanced 68.8±0.7 pg/ml, p<0.001, one-way ANOVA), and TGF-β (naïve 17.9±1.5, early 107.5±13.6, advanced 848.9±9.0 pg/ml, p<0.001, one-way ANOVA) were significantly elevated when the tumor progressed (Figs. 3D4–3D6). Here, IL6 is linked to neoplasm.