These last sets of data suggest that Warburg-phenotype TCs are resistant to lactate-induced HIF-1 activation under normoxia, which was confirmed using a second well-known Warburg-phenotype TC line [42]: similar to WiDr, HCT116 human colon carcinoma TCs did not activate HIF-1 in response to lactate (Figure S6B). Here, HIF1A is linked to colon carcinoma.