One way ANOVA demonstrated significant group effects in the expression of MC-1 (Fig. 3C; p<0.001) with post-hoc Tukey's test demonstrating significant effect of PbA infection on MC-1 expression when compared to either control or PbN mice, but no effect of PbN infection when compared to controls, illustrating that the post-translational modifications of tau protein were specific to ECM, and not simply due to severe malaria disease. The gene discussed is MAPT; the disease is infection.