Interest in γ-secretase comes in part from the fact that this enzymatic complex is responsible for the cleavage of amyloid precursor protein that generates the β-amyloid peptide, one of key components of amyloid plaques in Alzheimer’s disease [10] and in ischemic human brain injury [15, 16, 19, 21, 50]. Here, APP is linked to early-onset autosomal dominant Alzheimer disease.