CD4 and granulomatosis with polyangiitis: CD4+CD25highCD127low Tregs were increased in quiescent GPA (8.3 ± 3.5% in untreated patients, n = 22; 6.0 ± 1.1% in treated patients, n = 13) and active GPA (7.0 ± 2.8%, n = 18) compared to the HC (5.1 ± 1.0%, n = 13)(P < 0.006, P = 0.06, and P = 0.02 respectively, for comparison with the HC) (Figure 2A).