IFNγ+/IL-17A+CD4+ T cells were significantly increased in untreated, quiescent GPA (0.24 ± 0.18%, n = 24, P = 0.001), but not in treated, quiescent GPA (0.20 ± 0.18%, n = 15, P = 0.09), and in active GPA (0.19 ± 0.19%, n = 12, P < 0.05) compared to the HC (0.09 ± 0.07%, n = 14) (Figures 3B and 3C). This evidence concerns the gene CD4 and granulomatosis with polyangiitis.