Unlike previous studies on gastric carcinoma[18], colonic[20], and esophageal squamous cell carcinoma[29], we observed no significant correlation between high expression of Bmi-1 and esophageal adenocarcinoma and squamous cell carcinoma with other clinicopathologic features such as age, gender, stage, metastatic lymph nodes. The gene discussed is BMI1; the disease is esophageal squamous cell carcinoma.