KRT8 and liver disorder: Among them, keratins represent attractive candidates to serve as modifier genes in ALD, given that (i) keratins are established liver disease modifiers[4-6]; (ii) ALD leads to a characteristic redistribution of K8/K18 network with formation of Mallory-Denk bodies and keratin redistribution was previously shown to be affected by presence of keratin variants[7,8]; (iii) oxidative stress is an integral part of ALD and presence of keratin variants primes transgenic animals towards oxidative stress[9].