RICTOR and central nervous system cancer: Additionally, in a cell line (Ric0) derived from resected gliomas from newborn GFAP-Cre/RictorloxP/loxP mice expressed the Rictor transgene, stained positive for GalC and demonstrated hyperactivation of mTORC2 as compared to oligodendrocytes isolated from control littermates (Figure 2I–J).