While we initially postulated that HDAC are directly involved in mediating modulation of AXL transcription by EZH2 in gliomas, our data suggest that inhibition of HDAC suppress AXL transcription by transcriptional control of EZH2, indicating that EZH2 is under transcriptional control of HDAC also in malignant glioma. This evidence concerns the gene EZH2 and central nervous system cancer.