Ad·(ST13)·CEA·E1A(Δ24) treatment significantly inhibited but not completely eradicated the growth of xenograft SW620 colorectal carcinomas in nude mice, and the survival time was dramatically improved without one nude mice death in the Ad·(ST13)·CEA·E1A(Δ24) treated group. The gene discussed is CEACAM5; the disease is colorectal carcinoma.