In line with these findings, RNAi-mediated silencing of CD46, a receptor for entry of HHV6A, but not HHV6B [20], prevented HHV6A, but not HHV6B-mediated chlamydial persistence (Figure 2E,F), supporting the notion that entry of HHV6 is essential for inducing chlamydial persistence during co-infection. Here, CD46 is linked to coinfection.