Leading edge genes from the “proliferation control” network (Table 1) include many classic pro-proliferative genes such Ccna2 (CCNA2 in human), Cdc6, Tk1, and Gmnn. Leading edge genes in the “chemokines/growth factors” network (Table 2) include many involved in pathways that have proven links to prostate cancer, including chemokines/chemokine receptors (Ccl2, Cxcl5, Cxcr1, Cxcr2) [53],[54], the endothelin axis (Ednrb, Ednra) [55], and neuropeptides (Npy, Npy1r, Npy5r, Pyy) [56]. This evidence concerns the gene CXCR2 and Familial prostate cancer.