NKX3-1 and Familial prostate cancer: Increased expression of this pro-proliferative gene signature, consisting of classic proliferation genes (i.e. cyclins) and chemokines/growth factors, many of which have been implicated in prostate cancer [53], [54], [55], [56], may explain the increase in proliferation seen upon NAC treatment of the Nkx3.1−/− prostate.