ACE2 and breast cancer: Moreover, EXT increased ACE2 activity (LZR+EXT showed a 24% increase compared with LZR; p<0.05 and OZR+EXT showed a 30% increase compared with OZR; p<0.05), and protein expression (LZR+EXT showed a 74% increase compared with OZR; p<0.05 and OZR+EXT showed a 81% increase compared with OZR; p<0.05) in both trained groups irrespective of BC, demonstrating the beneficial effect of exercise per se on ACE2, (Figures 5a and 5b).