ANXA1 and neoplasm: Protein tyrosine phosphatase gene expression was shown to be up-regulated in stromal fibroblasts from human breast tumors [15], while our study showed PTPRC down-regulated in tumor stroma without annexin A1 (Table 1), this suggests that inhibiting annexin A1 may disrupt tumor stroma to hamper tumor progression via decreasing expression level of protein tyrosine phosphatase.