Based on our recent finding of pro-angiogenic functions for annexin A1 in vascular endothelial cell sprouting, wound healing, and tumor growth and metastasis [1], and the previously known properties for annexin A1 in immune cells and inflammation [4], this study hypothesized that annexin A1 is a key functional player in tumor development, linking the various components in tumor stroma by its actions in endothelial cells and immune cells. This evidence concerns the gene ANXA1 and neoplasm.