While the tumor cells were originally same before being implanted into annexin A1 ko and wt mice, therefore, the tumor stroma in annexin A1 ko and wt mice exhibited significant differences in the gene expression profiles between the host body with and without annexin A1, although the genes in tumor cells may change their expression levels due to the interaction between tumor cells and the tumor stroma. This evidence concerns the gene ANXA1 and neoplasm.