EGFR and cancer: In locally advanced disease, innovative approaches with 3D image-based BT boost and intensity modulated radiotherapy offer a potential for the individualised escalation of the target dose while respecting normal tissue tolerance.35 For the treatment of unresectable recurrences and distant metastases, the development of more active new anti-cancer drugs, for example epidermal growth factor receptor (EGFR) inhibitors may represent an option.