At present, of 55 genes known to be mutated in individuals with RP, most display allelic heterogeneity, and some have been implicated in both dominant and recessive modes of inheritance e.g., bestrophin 1 (BEST1), neural retina leucine zipper (NRL), nuclear receptor subfamily 2, group E, member 3 (NR2E3), rhodopsin (RHO), retinitis pigmentosa 1 (RP1), and retinal pigment epithelium-specific protein 65 kDa (RPE65); RetNet-Retinal Information Network; provided in the public domain by the University of Texas Houston Health Science Center, Houston, TX). The gene discussed is NR2E3; the disease is retinitis pigmentosa 1.