However, given the data at hand, and previous analysis of samples of different geographical and ethnical origins [Peerbooms et al., 2010; Saetre et al., 2011; Wang et al., 2011], a parsimonious interpretation is that our initial findings [Vares et al., 2010a] were due to chance alone, and that the MTHFR 677T-allele has no significant effect on the age at onset of schizophrenia in the general population, irrespective of the geographical location, ethnicity or genetic background. This evidence concerns the gene MTHFR and schizophrenia.