Copy number aberration, translocation and point mutation of human FAT1, FAT2, FAT3, FAT4, FRMD1, FRMD6, NF2, WWC1, WWC2, SAV1, STK3, STK4, MOB1A, MOB1B, LATS1, LATS2, YAP1 and WWTR1 genes should be comprehensively investigated in various types of human cancers using high-throughput sequencing technology to elucidate the mutation landscape of the FAT-Hippo signaling cascades. Here, FAT4 is linked to cancer.