CHUK and prostate carcinoma: Though it is known that inhibition of 5-Lox induces apoptosis in prostate cancer cells (20–25), and that WDL inhibits the activity of 5-Lox (17), WDL is not a specific inhibitor of 5-Lox because at higher doses it inhibits IKKα, topoisomerase IIα, trypsin and PLA2 (8–13,34).