The product of B*18:01 allele was associated with increased risk of AA/PNH and presented the oktapeptide GEDGRVYV [40] derived from phospholipase D (PI-PLD, phosphatidylinositol-glycan-specific phospholipase D, EC 3.1.4.50) [47], oktapeptide UEYARKUT [40] from 5-hydroxytryptamine 1F (5HT1F) receptor and nonapeptide DEKEKLQLV [40] from Hsp 47. This evidence concerns the gene GPLD1 and paroxysmal nocturnal hemoglobinuria.