An additional element of bone marrow failure in dual pathogenesis model of PNH clone dominance proposed by Luzzatto et al. [12, 13] and a hypocellular marrow environment element proposed by Young et al. [14] can be justified by excessive Treg activation and local induction of IFN-γ. The gene discussed is IFNG; the disease is paroxysmal nocturnal hemoglobinuria.