Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal nonmalignant disease caused by the somatic mutation of phosphatidylinositol glycan complementation group-A (PIG-A) gene located in chromosome Xp22.1 in hematopoietic progenitor cell [1]. The gene discussed is PIGA; the disease is paroxysmal nocturnal hemoglobinuria.