Furthermore, in addition to conferring susceptibility to sarcoidosis per se, HLA genotypes also predispose to specific disease phenotypes, the most persuasive evidence being the association between HLA-DQB1*0201 and DRB1*0301 and Löfgren’s syndrome - defined as the acute onset of fever, erythema nodosum, bilateral hilar lymphadenopathy and polyarthralgia [40]. The gene discussed is HLA-DRB1; the disease is sarcoidosis.