Multivariable adjusted (for variables entered into the model see methods section) positive predictors of incident hypoglycaemia over the 12 months follow-up were prior anamnestic hypoglycaemia (OR 4.05; 95%CI 3.04-5.39), pre-existent retinopathy (3.27; 1.07-30.02), pre-existent clinically relevant depression (1.81; 1.14-2.88), insulin use starting at baseline (2.99; 2.27-3.95) and blood glucose self-measurement (1.72; 1.23-2.41) (Figure2). This evidence concerns the gene INS and depressive symptom measurement.