Amongst patients receiving any type of monotherapy, insulin use was the only positive predictor of incident hypoglycaemia (OR 6.59; 95%CI 4.43-9.79) while the reduced rate with DPP-4 inhibitors was statistically only borderline significant (OR 0.52; 95%CI 0.26-1.03). This evidence concerns the gene INS and Hypoglycemia.