A particular role of anamnestic hypoglycaemia has previously been reported from intervention studies such as the Diabetes Control and Complications Trial (DCCT) and a study reporting on the effects of a teaching programme for intensification of insulin therapy where a history of severe hypoglycaemia was one of the main predictors for an increased risk of future severe hypoglycaemia[32,33]. Here, INS is linked to Hypoglycemia.