Overall, malignant B cells from SLL/CLL patients showed significant higher basal levels of several phospho-proteins, including p-SFKs, p-PLCγ, p-ERK, p-p38, p-p65 (NF-κB), p-STAT5 and p-STAT6, but the levels varied considerably between different patients. This evidence concerns the gene NFKB1 and B-cell chronic lymphocytic leukemia.