IGF2BP1 and cancer: Insulin-like growth factor 2 binding protein 1 (IGF2BP1) is an RNA-binding factor that regulates the translation of mRNAs produced by certain genes like IGF2 and ACTB. Increased expression of IGF2BP1 has been implicated in the development and progression of cancers of various organs, e.g. lung, brain, breast and colon[24-27].