IC50s of OFX for WT DNA gyrase was 5.7 μg/ml (Table 2) and it seemed reasonable that OFX has been used by a single application of 400 to 600 mg for leprosy patients with a single lesion and two or three doses of 400 to 600 mg in combination with first-line drugs, DDS and RIF [27] for the treatment of patients with MDR leprosy. This evidence concerns the gene TOP2A and leprosy.