Finally, our data showed significant relationships between M2RR preC/C mutations, though not the immuno-inactive region or M1RR mutations, and HCC patients [HCC (2.7%) vs. comparison group (1.9%), p = 0.024] (Table 3), suggesting that immune evasion against the CD4 T cell via HBcAg mutation contributes to hepatocarcinogenesis. This evidence concerns the gene CD4 and hepatocellular carcinoma.