Regardless, it appears important that future studies evaluate the potential clinical ramifications of the androgen-induced alterations in total adiponectin, given that low adiponectin is associated with risk of type II diabetes and several other metabolic conditions, and that low circulating adiponectin appears to precede the development of insulin resistance and myocardial infarction [1]. This evidence concerns the gene ADIPOQ and myocardial infarction.