Although evidence suggests its oncogenic character is mediated through the activation of NF-κB signaling [6], β-TrCP also facilitates the degradation of a wide array of tumor-promoting proteins, including β-catenin, Snail, ATF4, cdc25A, Mcl-1, cyclin D1, and Sp1 [7], [8], [9], [10], [11], [12], [13], thereby suppressing cancer cell proliferation and invasion. Here, SP1 is linked to cancer.