Analysis of the expression levels of Skp2 and β-TrCP in different prostate and breast cancer cell lines, including LNCaP, PC-3, DU-145, MCF-7, MDA-MB-231, and MDA-MB-468, revealed that these F-box proteins are differentially expressed among these cells (Fig. 1B). The gene discussed is BTRC; the disease is breast carcinoma.