Previously, we demonstrated that increased β-TrCP protein expression represents a cellular response to energy restriction induced by ERMAs, including CG-12 (structure, Fig. 1A) and 2-deoxyglucose (2-DG), or glucose depletion in cancer cells, from which the resulting degradation of cell cycle- and proliferation-regulatory proteins plays a crucial role in triggering downstream apoptosis signaling [18]. This evidence concerns the gene BTRC and cancer.