COL18A1 and neoplasm: Using custom microarrays which cover over 90% of the human genome [21], it has been reported that about 12% of genes are significantly regulated in human microvascular endothelial cells by endostatin, suggesting this reagent is a broad spectrum inhibitor of angiogenesis, Previous studies have demonstrated that a number of mechanisms contribute to the anti-angiogenesis or anti-tumor activities of endostatin, including interference with integrins, E-selectin and several metalloproteinases [24], [31], [32].