T cell-based immunotherapy is an attractive option for treatment of chemotherapy-refractory/high-risk NB patients, since NB expresses known T-cell tumor antigens from the MAGE family, GAGE, NY-ESO-1, PRAME, tyrosine hydroxylase, survivin, MYCN, and Anaplastic Lymphoma Kinase (ALK) [8]–[20]. This evidence concerns the gene PRAME and neuroblastoma.