Downstream correction of the stoichiometric insufficiency of IRF1 and NF-kB restores the presentation of tumor antigens in a model NB cell line, providing the proof of principle that complex immune escape phenotypes can be rescued by a limited number of master genes, and that NB can be made sensitive to CTLs that otherwise would be unable to recognize expressed, endogenous NB tumor antigens. This evidence concerns the gene IRF1 and neoplasm.