11 of the significantly differently regulated proteins involved in the apoptosis of cells were changed in a pro-apoptotic manner whereas 8 proteins were changed in an anti-apoptotic manner.BAK1 was found to be down-regulated in the cells incubated with POAG Abs, whereas it was up-regulated in the cells incubated with POAG serum. This evidence concerns the gene BAK1 and open-angle glaucoma.