In the cells incubated with POAG serum we found, that several of the proteins involved in the apoptosis of cells, e.g. BAX (5 fold up-regulated), BAK1 (22.9 fold up-regulated), PARP1 (8.8 fold down-regulated) and GAS2 (7.8 fold up-regulated), were significantly differently regulated in a pro-apoptotic manner. The gene discussed is BAK1; the disease is open-angle glaucoma.