IGF1 and neoplasm: Several IGFBP-2 in vitro and in vivo models suggested that binding of IGFs by IGFBP-2 has growth-inhibitory consequences, and other functions of IGFBP-2 such as stimulating cell proliferation in an IGF-independent manner must be taken into account when the correlation between IGFBP-2 and tumor growth is examined [37].