CYP1A1 and neoplasm: Although the up-regulation of CYP1A1 does not appear to be the main event by which Triflorcas elicits its anti-tumor effects, we cannot exclude that, in some neoplastic cells, the modulation of anticancer pharmaceuticals by CYP1A1 may prove to be an advantage above additional mechanisms of action of 2-phenylimidazo[2,1-b]benzothiazole derivatives.